The difference between fillers and Botox lies in their ingredients, function, and purpose. Botox is a neurotoxin that, when injected, blocks certain nerves from receiving signals that trigger movement. This prevents the repeated facial expressions that lead to fine lines and wrinkles, without removing your ability to express. Fillers are gels that typically stay beneath the surface of your skin to add volume and support. This achieves a more youthful and restored appearance and can improve facial contours.